Features of inhibiting butyrylcholinesterase and carboxylesterase hydrolysis with fluoranhydride esters of beta,beta-diphenylethylphosphonic acid
Brestkin, A.P.; Efimtseva, E.A.; Kuznetsova, L.P.; Nikol'skaia, E.B.; Fridland, S.V.
Biokhimiia 61(3): 472-479
1996
ISSN/ISBN: 0320-9725 PMID: 8724606 Document Number: 462969
A new type of organophosphorus compounds-beta, beta-diphenylethylphosphonic acid fluoroanhydride esters-with various alkyl radicals (CH3, C2H5, C3H7, i-C3H7, C4H9, i-C4H9, C5H11, C6H13) and a phenyl radical (C6H5) have been tested as inhibitors of horse serum butyryl cholinesterase (EC 3.1.1.8) and two forms of reindeer liver carboxyl esterase (EC 3.1.1.1). All the tested compounds are strong irreversible inhibitors of butyryl cholinesterase and strong combined type inhibitors of carboxylesterase. The values of inhibitory constants have been found to depend on the structure of the alkyl radical in the inhibitor molecule.