Pharmacokinetics of bleomycin after im administration in man
Oken, M.M.; Crooke, S.T.; Elson, M.K.; Strong, J.E.; Shafer, R.B.
Cancer Treatment Reports 65(5-6): 485-489
1981
ISSN/ISBN: 0361-5960 PMID: 6165473 Document Number: 172495
The pharmacokinetics of bleomycin were studied after im injection in patients with malignant lymphoma. Mean peak serum concentrations of 0.133, 0.326, and 0.587 milliunits/ml were obtained approximately 1 hour after injection of 2, 5, and 10 units/m2, respectively. The mean half-life was 155 minutes, with a range of 65--235 minutes. Thirty-three percent of the administered dose was recovered in the urine after 4 hours. The urinary excretion of bleomycin was 61% during the 24 hours after injection, with some variability that was not explained by differences in dose or creatinine clearance.