Dependence of galodif pharmacokinetics on duration of its administration
Kanov, E.V.; Novozheeva, T.P.; Saratikov, A.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 65(2): 56-58
2002
ISSN/ISBN: 0869-2092 PMID: 12109296 Document Number: 547401
Pharmacokinetics of the new antiepileptic drug galodif was experimentally studied on rats. A single administration of the anticonvulsant is followed by slow elimination. A five-day administration leads to a significant acceleration of the drug elimination due to activation of the cytochrome P-450 dependent monooxygenase system of liver. After a 14-day administration, the elimination rate decreases as compared to that for the five-day treatment, while being still higher than in the case of single administration.