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Pharmacokinetics of heparin. I. Studies of dose dependence in rats

Bjornsson, T.D.; Levy, G.

Journal of Pharmacology and Experimental Therapeutics 210(2): 237-242

1979

ISSN/ISBN: 0022-3565
PMID: 458630
Document Number: 150174
The effect of dose on the elimination kinetics of heparin in rats was investigated. Adult male Sprague-Dawley rats received i.v. injections of different doses of heparin (150, 300 and 500 Uheparin was administered alone. There appear to be at least 2 dose-dependent aspects of heparin elimination in rats. The disposition of heparin in man is also dose dependent so that the rat may be a useful model for investigating the mechanism of the unusual pharmacokinetics of this important anticoagulant drug.

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