Technetium 99m labelled heparin: pharmacokinetics and tissue distribution in rats after vascular surgery
Colas-Linhart, N.; Berthelot, J.L.; Ducret, A.; Petiet, A.; Bok, B.
Biomedicine and PharmacoTherapy 41(4): 189-191
1987
ISSN/ISBN: 0753-3322 PMID: 3620586 Document Number: 290473
Pharmacokinetics of technetium 99m (99mTc) labelled heparin was studied after I.V. infusion (70 IU/kg) in normal rats and in a group of animals just after aortic longitudinal incision and suture. Anticoagulant activity measurements and radioactivity were compared on the same plasma samples. The pharmacokinetic decay of 99mTc-heparin followed a bi-exponential pattern. Half-lives (T1, T2) were significantly shortened after surgery using both techniques. Liver accumulation of labelled heparin was decreased in "sutured" rats and a high uptake of 99mTc-heparin was found on the operated area of the aorta.