Influence of the adrenergic system on lipid metabolism in skeletal muscles during their stimulated contractions
Grzymisławski, M.; Paluszak, J.
Acta Medica Polona 22(2): 119-125
1981
ISSN/ISBN: 0001-608X PMID: 6119006 Document Number: 172191
The effect of blockade of adrenergic receptors on lipid metabolism was studied in situ in a muscle group of dog leg subjected to contractions. Free fatty acids (FFA), triglycerides (TG) and lipid mobilizing activity (LMA) were studied in arterial blood and in venous blood outflowing from the studied muscle group. FFA were not taken up by the muscle group at rest, either when the receptors remained unblocked or under .alpha.-adrenergic receptor blockade. During contractions or restitution the arterio-venous difference in FFA levels showed positive values both in control animals and in those with .alpha.- or .beta.-adrenergic receptors blocked. LMA in serum of arterial blood increased in the control group during contractions and during restitution, and at rest following administration of regitine. In venous blood LMA increased during contractions in control animals and both during contractions and at rest in dogs with .alpha.-adrenergic receptors blocked. Propranolol administration decreased LMA in venous blood to negative values. In studied conditions no significant changes in triglyceride level were noted in arterial or venous blood. Changes in blood flow through the studied muscle group, induced by agents acting on adrenergic receptors, constitue the principal cause of changes in lipid metabolism.