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Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat live tissue using phenobarbital

Chistiakov, V.V.; Prikhod'ko, A.Z.

Voprosy Meditsinskoi Khimii 27(3): 340-342

1981

ISSN/ISBN: 0042-8809
PMID: 7281573
Document Number: 171454
A preadministration of testosterone propionate into rat females within 8 days caused an increase in the inducing effect of phenobarbital (after its single injection) on the content of cytochrome P-450 in liver tissue. The administration of testosterone did not affect the content of the enzyme in liver tissue. A shown in the experiments on phenobarbital induction of the enzyme as a function of duration of testosterone administration, two maximal peaks, within 1 and 8 days, were observed after preadministration of the hormone. The hormone influenced mainly on the rate of the increase in cytochrome P-450 content but not on degree of its induction.

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