Effect of the long term administration of bromantan on the reproductive function in rats
Khamidova, T.V.; Bugaeva, L.I.; Morozov, I.S.; Spasov, A.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 63(3): 36-39
2000
ISSN/ISBN: 0869-2092 PMID: 10934594 Document Number: 6637
Bromantan is a new psychostimulator possessing actoprotector properties. The drug was administered to rats over two months (males) and two weeks (females) at a daily dose of 30 and 200-mg/kg, and the reproduction function parameters were monitored. Then the experimental animals were coupled and the embryonal characteristics of the breed were determined. Upon termination of the drug administration, the functional state of sperm and the morphology of gonads were studied again. It was found that bromantan (30 mg/kg) unreliably decreases the absolute amount of sperm in males. In females, the drug did not affect the ovary weight coefficient and increased the gestation index. After termination of the drug administration, the ovary weight coefficient increased. Bromantan affected neither the fertilizing capacity of male and female gametes nor the embryonal characteristics of the breed.
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