Top Abstract Purchase Related
Home
>
Node
>
Subnode

On the mechanism which mediates the effects of long-term administration of fencamfamine in rats

Planeta, C.S.; DeLucia, R.; Aizenstein, M.L.; Scavone, C.

Brazilian Journal of Medical and Biological Research 22(7): 881-883

1989

ISSN/ISBN: 0100-879X
PMID: 2576524
Document Number: 330685
This study analyzes the changes in the sensitivity of striatal dopaminergic (DA) receptors to apomorphine following withdrawal from long-term treatment with fencamfamine (10 mg/kg, for 40 days). Fencamfamine treatment decreased (34.8 +/- 3.2 vs 25.8 +/- 2.8, P less than 0.05) the stereotyped behavior induced by apomorphine (2.0 mg/kg, sc), but potentiated the effect of apomorphine (0.02 mg/kg, sc) in reducing the striatal levels of homovanillic acid (HVA) (0.41 +/- 0.02 micrograms/g vs 0.31 +/- 0.03 micrograms/g, P less than 0.01) and dihydroxyphenylacetic acid (DOPAC) (0.45 +/- 0.04 micrograms/g vs 0.34 +/- 0.03 micrograms/g, P less than 0.01). These results suggest that changes in pre- or postsynaptic DA receptors may underlie the tolerance and sensitization to the effects of fencamfamine.

Document emailed within 1 workday
Secure & encrypted payments

Bryson, G.; Reynolds, R.W. 1981: Effects of adrenocortical stress responses and metabolic functions during and after long-term administration of dexamethasone to adult Evans-Long rats Research Communications in Chemical Pathology and Pharmacology 34(2): 267-286
Tandon, P.; Barone, S.; Drust, E.G.; Tilson, H.A. 1991: Long-term behavioral and neurochemical effects of intradentate administration of colchicine in rats Neurotoxicology 12(1): 67-77
Ramos-Ramirez, E.G.; Lazgare-Bello, C.; Morales-Aguilera, A. 1983: Effects of long-term administration of anthracene-9-carboxylic acid (9-AC) on young and adult rats Proceedings of the Western Pharmacology Society 26: 21-23
Kuwa, K.; Sakamoto, S.; Sassa, S.; Yoshimura, S.; Maemura, M.; Nakayama, T. 1999: Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats Anticancer Research 19(6b): 5139-5142
Hess, M.E.; Haugaard, N.; Min, W.; Torbati, A. 1986: Metabolic effects of acarbose in normal and diabetic rats: long- and short-term administration Archives Internationales de Pharmacodynamie et de Therapie 283(1): 163-176
Fontaine, J.; Neve, J.; Peretz, A.; Pelen, F.; Famaey, J.P. 1989: Comparison of effects of chronic inflammation and long-term prednisolone administration on zinc metabolism in rats International Journal of Tissue Reactions 11(5): 253-259
Maltoni, C.; Tovoli, D. 1979: First experimental evidence of the carcinogenic effects of vinylidene fluoride; long-term bioassays on Sprague-Dawley rats by oral administration La Medicina del Lavoro 70(5): 363-368
Patwardhan, R.V.; Schenker, S.; Henderson, G.I.; Abou-Mourad, N.N.; Hoyumpa, A.M. 1981: Short-term and long-term ethanol administration inhibits the placental uptake and transport of valine in rats Journal of Laboratory and Clinical Medicine 98(2): 251-262
Schreiber, V.; Kapitola, J.; Schreiberová, O. 1972: Radioiodine uptake by thyroid during long-term administration of theophylline in rats Endocrinologia Experimentalis 6(1): 29-32
Khamidova, T.V.; Bugaeva, L.I.; Morozov, I.S.; Spasov, A.A. 2000: Effect of the long term administration of bromantan on the reproductive function in rats Eksperimental'naia i Klinicheskaia Farmakologiia 63(3): 36-39
Chlumská, A. 1982: Findings in the liver tissue of rats after long-term administration of high doses of Biogest Ceskoslovenska Patologie 18(3): 176-182
Li, J.; Olvera, A.I.; Akbari, O.S.; Moradian, A.; Sweredoski, M.J.; Hess, S.; Hay, B.A. 2015: Vectored antibody gene delivery mediates long-term contraception Current Biology: Cb 25(19): R820-R822
Shimpo, K.; Tanabe, T.; Togashi, H.; Kawakita, I.; Shimakage, K. 1975: On the toxicity of CT-1341 evoked by long-term administration. II. Subacute and chronic toxicities of alphaxalone in rats Hokkaido Journal of Medical Science 50(1): 55-69
Vorhees, C.V.; Rindler, J.M.; Minck, D.R. 1990: Effects of exposure period and nutrition on the developmental neurotoxicity of anticonvulsants in rats: short and long-term effects Neurotoxicology 11(2): 273-283
Hong, J.S.; Yang, H.Y.; Gillin, J.C.; Costa, E. 1980: Effects of long-term administration of antipsychotic drugs on enkephalinergic neurons Advances in Biochemical Psychopharmacology 24: 223-232
Alekseeva, L.I.; Arkhangel'skaia, G.S.; Davydova, A.F.; Karmil'tseva, E.A.; Kogan, K.M.; Mazurov, V.I.; Rebrov, A.P.; Riabitseva, O.F.; Shemerovskaia, T.G.; Iakushin, S.S. 2003: Long-term effects of structum administration (according to data from multicenter trial) Terapevticheskii Arkhiv 75(9): 82-86
Khaliq, S.; Haider, S.; Siddiqui, M.; Sherwani, S.K.; Sajid, I.; Mustafa, S.; Ejaz, T. 2017: Enhancement in spatial and recognition memory functions following long term oral administration of ginger extract in rats Pakistan Journal of Pharmaceutical Sciences 30(6): 2061-2066
Braun-Dullaeus, R.C.; Feussner, M.; Walker, G.; Tillmanns, H.; Haberbosch, W. 1998: Comparison of in vitro cardiovascular function with in vivo echocardiographic assessment after long-term administration of cyclosporine to rats Journal of Cardiovascular Pharmacology 31(6): 828-832
Orrego, H.; Crossley, I.R.; Saldivia, V.; Medline, A.; Varghese, G.; Israel, Y. 1981: Long-term ethanol administration and short- and long-term liver regeneration after partial hepatectomy Journal of Laboratory and Clinical Medicine 97(2): 221-230
Flöter, T.; Brunnmüller, U. 2002: Tilidine/naloxon retard in long-term administration in chronic pain and multimorbidity. Multicenter study of long-term tolerance and effectiveness in 2 years observation Fortschritte der Medizin. Originalien 120(1): 29-35