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Induction of cytochrome P-450 forms by prolonged administration of nifedipine

Guliaeva, L.F.; Grishanova, A.I.; Mishin, V.M.; Koleva, M.; Stoĭchev, T.; Liakhovich, V.V.

Biulleten' Eksperimental'noi Biologii i Meditsiny 109(2): 148-150

1990

ISSN/ISBN: 0365-9615
PMID: 2337647
Document Number: 364801
In experiments on male Wistar rats it has been found that nifedipine applied in a dose of 10 mg/kg body weight i.p. daily for 20 days did not significantly increase the total amount of cytochrome P-450 but markedly increased the 7 alpha-, 16 beta- and 6 beta-hydroxylation of androstenedione in liver microsomes, suggesting the induction of cytochromes P-450a, P-450b and P-450p respectively. The induction of cytochrome P-450b was also confirmed immunochemically with polyclonal antibodies against cytochrome P-450b/e.

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