Distant angiogenesis in a patient with glioblastoma multiforme
Romberger, C.F.; Wollman, R.L.; Wainer, B.H.
Clinical Neuropathology 9(2): 97-100
1990
ISSN/ISBN: 0722-5091 PMID: 1692777 Document Number: 364800
The case of a 42-year-old man with a cerebral glioblastoma multiforme associated with marked neovascularization of the arachnoid of the brain stem and spinal cord is reported. All of the neurological symptoms and signs were referrable to the glioblastoma and resultant craniotomies. The arachnoid contained a proliferation of well differentiated blood vessels. This neovascularization occurred in the absence of local tumor or inflammation. We suggest that the neovascularization resulted from release of a tumor angiogenesis factor into the cerebrospinal fluid.