An investigation into the effects of chloroquine on fertility of male rats
Okanlawon, A.O.; Noronha, C.C.; Ashiru, O.A.
West African Journal of Medicine 12(2): 118-121
1993
ISSN/ISBN: 0189-160X PMID: 8398931 Document Number: 171
We investigated the effect of chloroquine on the fertility of adult male rats. Rats were administered chloroquine at a daily infra-peritoneal dose of 10mg/kg body weight and 40mg/kg body weight per rat, five days a week for 16 weeks. Females mated with treated males showed a dose dependent decrease in the number of litter per female rat. In the in-vitro studies, more than 80% os spermatozoa were immotile in all concentrations of chloroquine tested. These results suggest that chloroquine brings about its antifertility effect by decreasing sperm motility.
Document emailed within 1 workday
