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Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution

Wilson, I.A.; Skehel, J.J.; Wiley, D.C.

Nature 289(5796): 366-373

1981

ISSN/ISBN: 0028-0836
PMID: 7464906
Document Number: 170039
The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of alpha-helices extends 76 A from the membrane and a globular region of antiparallel beta-sheet, which contains the receptor binding site and the variable antigenic determinants, is positioned on top of this stem. Each subunit has an unusual loop-like topology, starting at the membrane, extending 135 A distally and folding back to enter the membrane.

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Suzuki, H.; Yamazaki, H.; Tanoue, K. 1992: Platelet structure and function: immunocytochemical localizations of membrane glycoprotein and alpha-granule protein Nihon Rinsho. Japanese Journal of Clinical Medicine 50(2): 218-222
Johannsen, R.; Hinz, J.; Gruschkau, H. 1986: Pitfalls of single radial immunodiffusion techniques used for the quantification of influenza haemagglutinin Developments in Biological Standardization 65: 255-260
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Fuller, S.D.; von Bonsdorff, C.H.; Simons, K. 1985: Cell surface influenza haemagglutinin can mediate infection by other animal viruses EMBO Journal 4(10): 2475-2485
Zhilinskaia, I.N.; Tets, V.V.; Golubev, D.B. 1978: Genome structure of influenza virus Voprosy Virusologii 4: 387-394
Enami, M. 1997: Structure and function of influenza virus NS1 and NS2 proteins Nihon Rinsho. Japanese Journal of Clinical Medicine 55(10): 2605-2609
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Markushin, S.G.; Ginzburg, V.P.; Khaĭder, A.M.; Iarosh, V.V.; Ivas'ko, E.A.; Klimov, A.I. 1992: Factors that cause a change in the antigenic structure of of the influenza virus hemagglutinin Voprosy Virusologii 37(4): 196-199
Arbatskiĭ, N.P.; Zheltova, A.O.; Iurtov, D.V.; Kharitonenkov, I.G.; Abashev, I.P.; Derevitskaia, V.A.; Kochetkov, N.K. 1990: The structure of carbohydrate chains of hemagglutinin and neuraminidase of influenza virus B/Leningrad/179/86 Bioorganicheskaia Khimiia 16(6): 801-807
Petrov, N.A.; Grinev, A.A.; Vasilenko, S.K.; Zhilinskaia, I.N.; Paramonova, M.S. 1988: Structure of the hemagglutinin gene of the influenza virus during serial passages in chick embryos Biulleten' Eksperimental'noi Biologii i Meditsiny 106(11): 596-598
Samuel, I.; Tomas, E.; Bîrnaure, F. 1978: The effect of rat and rabbit ceruloplasmin on the multiplication of two influenza virus strains in the chorioallantoic membrane of embryonated hen eggs Virologie 29(4): 301-303
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Petrov, N.A.; Golovin, S.I.; Mamaev, L.V.; Netesov, S.V.; Vasilenko, S.K. 1987: Primary structure of the full-size DNA copy of the influenza virus A/Kiev/59/79 (H1N1) PB1 gene protein Bioorganicheskaia Khimiia 13(9): 1170-1175
Reĭzin, F.N.; Chumakov, M.P.; Mart'ianova, L.I. 1982: Stabilization of the influenza virus by normal serum. Increase in the infectious activity of the influenza virus in chick embryos Voprosy Virusologii 27(5): 106-109