Structure-function relationship of the influenza virus RNA polymerase subunits
Toyoda, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 55(10): 2593-2598
1997
ISSN/ISBN: 0047-1852 PMID: 9360377 Document Number: 483150
Influenza virus RNA polymerase with the subunit structure PB1-PB2-PA is involved in both transcription and replication of the RNA genome. PB1 is the catalytic subunit and binds both to PB2 in its N-terminus and to PA in its C-terminus. PB2 is required for priming with cap and binds to PB1 in its N-terminus. PA is required for cRNA-->vRNA synthesis of genome replication and binds to PB1 in its C-terminus. Therefore, PB1 is the core subunit not only for RNA polymerase activity but also complex formation of the enzyme. Protease activity is identified in the N-terminal region of PA, but its role on viral proliferation remains unknown.