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Prognostic role of thyroid transcription factor-1 (TTF-1) in advanced and inoperable adenocarcinoma subtype of lung cancer among Thai patients

Maneechawakajorn, J.; Benjawongsathien, D.

Journal of the Medical Association of Thailand 97(Suppl 11): S11-S17

2014

ISSN/ISBN: 0125-2208
PMID: 25509690
Document Number: 16799
To determine the role of thyroid transcription factor-1 (TTF-1) as a prognostic factor in advanced adenocarcinoma of non-small cell lung cancer. Retrospective cohort study among lung cancer patients with inoperable or metastases, adenocarcinoma type whose tumors were already tested for TTF-1 in Rajavithi Hospital from December 2003 to November 2011. The correlation of TTF-1 to survival period and the treatment outcomes were defined. Of 67 patients, 48 TTF-1 positive cases and 19 TTF-1 negative cases were included in the analysis. Median overall survival for all population was 263 days (111-415 days). No significant difference was found between TTF-1 positive and negative tumors (251 and 369 days, p-value = 0.8). The systemic treatment with chemotherapy was the only effective prognostic factor for survival of this study. The prognostic factor of TTF-1 positive and negative in advanced adenocarcinoma subtype of NSCLC was not different in median overall survival.

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