Ultrastructure of female rat FSH gonadotrophs following two LH-RH stimulations
Seinsch, W.; Haase, F.; Römmler, A.
Anatomischer Anzeiger 148(3): 207-213
1980
ISSN/ISBN: 0003-2786 PMID: 6784605 Document Number: 167716
In FSH-cells of female rats increased granule extrusion and increased granule synthesis was observed using electron-microscopy 60 min and 60--120 min, respectively, after a single 250 microgram LH-RH injection. Granule content was distinct higher 120 min after LH-RH when compared with NaCl treated animals. These "excessively" synthesized granules were subsequently removed by increased cytolysosomal degradation. When a second LH-RH injection of the same dose was given 120 min. after the first, a distinct augmentation of granule extrusion, -synthesis and -degradation was observed indeed in the same time-sequence as observed after the first LH-RH stimulation. As reported previously for LH, also FSH is secreted from FSH gonadotrophs by in toto granule extrusion. Subsequently the granule content was immediately restored by intracellular regulatory processes.