Optimization of the makeup of the fermentation nutrient medium for detecting antibiotic producers among Micromonospora
Bibikov, M.V.; Selekhova, G.N.; Vostrov, S.N.; Ivanitskaia, L.P.; Fishman, V.M.
Antibiotiki 25(12): 899-904
1980
ISSN/ISBN: 0003-5637 PMID: 7469394 Document Number: 167113
An optimal fermentation medium for detection of antibiotic-producing cultures among Micromonosporaceae at the stage of primary screening was developed. The method of the experiment factor design with regard both for the qualitative and the quantitative variation of the medium composition was used. The number of the active strains detected with the use of medium M1 amounts to 76.4 per cent of the cultures tested. The same efficiency was observed with simultaneous use of 6 different fermentation media. The use of the new medium significantly decreases the labour-consuming character of the procedure.