Interaction of cholesterol with apoprotein e - an arginine-rich protein of very low density lipoproteins
Titova, G.V.; Kliueva, N.N.; Kozhevnikova, K.A.; Klimov, A.N.
Biokhimiia 45(1): 51-55
1980
ISSN/ISBN: 0320-9725 PMID: 7213839 Document Number: 166228
Apoprotein E was isolated from delipidated lipoproteins of very low density obtained from blood plasma of rabbits with experimental hypercholesterinemia. The protein, whose molecular weight is 45000, produces a single hand during polyacrylamide gel electrophoresis and contains 10% of arginine. The formation of an apoprotein E -- cholesterol complex and participation of guanidine groups of guanidine groups of arginine residues of apoprotein E in cholesterol binding have been postulated.