Impairment of cholesterol-acceptor function of high density lipoproteins in patients with ischemic heart disease
Parfenova, N.S.; Petrova-Maslakova, L.G.; Kuznetsov, A.S.; Ioffe, D.V.; Alksnis, E.G.
Voprosy Meditsinskoi Khimii 34(2): 42-46
1988
ISSN/ISBN: 0042-8809 PMID: 3400190 Document Number: 311037
An ability of high density lipoproteins HDL3 to accept cholesterol from erythrocyte membranes was studied in healthy persons and in patients with ischemic disease of heart. The cholesterol-acceptory function was estimated as follows: by incorporation of fluorescent probes (cholestatriene and pyrene) into particles of HDL3, by elimination of cholesterol from erythrocyte membranes and by increase of the lipoproteins size evaluated using the method of quazi-resilient dispersion of laser light. In ischemic disease of heart the property of high density lipoproteins, specifically of HDL3 fraction, to accept cholesterol from cell membranes was impaired. Middle size of HDL3 particles was decreased in the patients with ischemic heart disease as compared with that of healthy persons.