Role of the microsomal enzymatic activity changes induced by peloid applications in the biotransformation and effect of pharmacological preparations
Leshchinskiĭ, A.F.; Zolotareva, T.A.; Golovenko Nia; Stepanova, E.I.
Farmakologiia i Toksikologiia 43(6): 705-708
1980
ISSN/ISBN: 0014-8318 PMID: 7450009 Document Number: 165200
Body exposure to the physical therapeutic factor (skin applications of heated peloid) leads to the acceleration of hydroxylase reactions proceeding on cytochrome P450. This circumstance determines the speeding up of the biotransformation of a number of pharmacological agents (strychnine, aniline, amidopyrine, etc.), and changes in the action of some drugs (phenobarbital, amidopyrine,, ethazole) affecting the drug-metabolizing microsomal system.