The influence of inhaled ketone solvent vapors on hepatic microsomal biotransformation activities
Couri, D.; Hetland, L.B.; Abdel-Rahman, S.; Weiss, H.
Toxicology and Applied Pharmacology 41(2): 285-289
1977
ISSN/ISBN: 0041-008X PMID: 898199 Document Number: 114995
In studies conducted to determine the effects of inhaled ketone (methyl n-butyl ketone, MBK; methyl ethyl ketone, MEK) solvent vapors on hepatic microsomal oxidative and reductive enzyme activities in rats, groups of young male Wistar rats were housed in environmental chambers and exposed to solvent vapors (MBK, 225 ppm; MEK, 750 ppm; MBK, 225 ppm; MEK, 750 ppm). Hexobarbital sleep times were significantly reduced following exposure to MBK/MEK or MEK, but MBK exposure did not alter sleep time measurements. Aniline hydroxylase, aminopyrine demethylase, Neoprontosil reductases and p-nitrobenzoate reductase activities were significantly enhanced 2- to 3-fold over control values.