State of energy metabolism and microsomal monooxygenases in animals exposed to inhaled 1,2,4-trimethylbenzene
Shakirov, D.F.; Farkhutdinov, R.R.; Zul'karnaev, T.R.
Gigiena i Sanitariia 4: 44-49
1999
ISSN/ISBN: 0016-9900 PMID: 10465878 Document Number: 507658
The investigations demonstrate that unfavourable changes occur in the tissues and red blood cells of the animals exposed to a single dose of 1,2,4-trimethylbenzene (TMB) in a concentration of 10 mg/m3; moreover, the inclusion of 32P is increased in the biochemical structures of the animals and the concentrations of Na, K, Mg, and Ca ions change. Exposure to TMB, 0.01-1.0 mg/m3 causes profound changes in the animals. Microsomal monooxygenases were found to activate in the lung, liver, and kidney of the animals exposed to TB in concentrations of 10 and 1 mg/m3.