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Foot-and-mouth disease virus production in glass sphere based monolayer systems of 0.1 to 100 L medium volume

Whiteside, J.P.; Whiting, B.R.; Spier, R.E.

Developments in Biological Standardization 46: 187-189

1980

ISSN/ISBN: 0301-5149
PMID: 6244996
Document Number: 163393
The cell and virus productivity of a 3 mm glass sphere based unit process monolayer system was determined at scales of 0.1, 1, 10 and 100 litres medium capacity. Enhanced yields were obtained up to the 10L size when compared with control Roux bottle cultures. Modifications of the operating conditions of the 100L system should bring this into line with the smaller-scale units.

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