Potassium, magnesium, copper, manganese and cobalt salts of aspartic acid on platelet factor 3 availability
Reuter, H.D.; Schröter, G.
Arzneimittel-Forschung 30(12): 2106-2108
1980
ISSN/ISBN: 0004-4172 PMID: 7194069 Document Number: 160189
Inzolen, a combination of the potassium, magnesium, copper, manganese and cobalt salts of aspartic acid, inhibits the second phase of ADP-induced aggregation probably by affecting the membrane-located adenylatecyclase/phosphodiesterase system. Correspondingly inzolen affects the activation of platelet factor 3 (PF3), which is also located in the platelet membrane. Thus spontaneous as well as kaolin-induced platelet factor availability is reduced by inzolen. The significant inhibition of factor 3 availability can be interpreted by a magnesium-mediated activation of phosphoryltransferases.