Sex steroid receptors in endometrial hyperplasia and neoplasia
Gurpide, E.
Acta Cytologica 24(6): 483-485
1980
ISSN/ISBN: 0001-5547 PMID: 6934674 Document Number: 159168
Receptors for steroid hormones are necessary for hormonal action. All tissues which are targets for hormonal action contain receptors. Estrogens seem to be required to induce progesterone receptor. Progesterone, in turn, has been shown to lower the level of estradiol receptors in the endometria of normal women. This would be likely to prevent the development of endometrial hyperplasia, a known precursor of endometrial cancer. Progesterones are, thus, related to endometrial cancer as both antagonists of estrogens and as therapeutic agents.
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