Studies on the shift of cefmetazole into the gastrointestinal tract
Minamitani, M.; Hayashi, H.; Tohma, T.; Kojima, T.; Sahashi, Y.; Terao, T.
Japanese Journal of Antibiotics 33(1): 10-17
1980
ISSN/ISBN: 0368-2781 PMID: 6929355 Document Number: 159169
From the studies on the stability of cefmetazole and cefazolin in feces of animals and children, and the determination of the fecal concentration of cefmetazole in three pediatric patients, the following results were obtained. 1) When cefmetazole was kept at 37 degrees C for 24 approximately 48 hours in feces of rats, rabbits, dogs and children, it showed no decrease of the potency. On the other hand, cefazolin kept in the same condition as that of cefmetazole showed a remarkable decrease of the potency. 2) Fecal excretions of cefmetazole were 0, 0.22 and 0.65% of total doses, respectively, in two pediatric patients of scarlet fever and one pediatric patient of serous meningitis.