Nicotine and the gastrointestinal tract
Clodi, P.H.
Wiener Medizinische Wochenschrift 138(6-7): 132-134
1988
ISSN/ISBN: 0043-5341 PMID: 3394326 Document Number: 310847
Reflux esophagitis occurs much more often in smokers because of reduction of saliva production and lessened tonus of the LES (lower esophageal sphincter). Duodenal ulcers heal during H2-blocking agents in smokers slower than during placebo-therapy in non smokers. Mortality of duodenal ulcer in smokers is 2 to 7 times increased.
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