Identification of radiolabeled metabolites of nicotine in rat bile. Synthesis of S- (-) -nicotine N-glucuronide and direct separation of nicotine-derived conjugates using high-performance liquid chromatography
Seaton, M.J.; Vesell, E.S.; Luo, H.; Hawes, E.M.
Journal of Chromatography 621(1): 49-53
1993
ISSN/ISBN: 0021-9673 PMID: 8308087 Document Number: 406180
Four metabolites of nicotine, including two glucuronides, have been separated by high-performance liquid chromatography. This separation was applied to identification of biliary metabolites of radiolabeled nicotine by radiometric detection. S-(-)-Nicotine N-glucuronide was synthesized and used as a standard in method development.
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