Tissue residue depletion and recycling of sulfamethazine in swine
Whipple, D.M.; Samuelson, G.; Heath, G.E.; Showalter, D.H.
Journal of the American Veterinary Medical Association 176(12): 1348-1352
1980
ISSN/ISBN: 0003-1488 PMID: 7429930 Document Number: 157887
Sulfadimidine was fed to weanling pigs at the rate of 100 g/ton of ration for 98 days to investigate the depletion rate of the drug from the plasma and edible tissues of swine. The mean plasma concentration of sulfadimidine for 21 treated pigs peaked at 10.8 ppm on day 77 of the 98-day treatment period. Concentrations in kidney, liver, skeletal muscle, and subcutaneous fat were at or below 0.1 ppm within 7 days after withdrawal of medicated feed. Depletion from tissues and plasma of the treated pigs showed a linear relationship with time when values were plotted on a semilogarithmic graph. Six of seven untreated pigs that were placed in the pens formerly occupied by the treated pigs accumulated drug residues in their kidney and liver tissues, at or above 0.1 ppm within 5 to 14 days.