Drug withdrawal from farmed fish. Depletion of oxytetracycyline, sulfadiazine, and trimethophrim from muscular tissue of rainbow trout (Salmo gairdneri)
Salte, R.; Liestøl, K.
Acta Veterinaria Scandinavica 24(4): 418-430
1983
ISSN/ISBN: 0044-605X PMID: 6675454 Document Number: 220987
A statistical approach to the setting of withdrawal times is presented. The time intercept between detection limit of the applied method of analysis, and the 90% upper prediction limit of a linear regression on the logarithm of the tissue drug concentration probably provides a realistic estimate of the necessary withdrawal period at the temperatures considered. Recognizing that water temperature is an important determinant of pharmaco-kinetics in fish, temperature-dependent withholding periods are recommended; i.e., 60 days at temperatures above 10.degree. C and, for oxytetracycline, 100 days at temperatures between 7 and 10.degree. C. The observed persistence of sulfadiazine and trimethoprim at lower water temperatures indicates that this drug mixture should be applied to slaughter fish only during summer.