Elimination of sulfamethazine residues from swine
Samuelson, G.; Whipple, D.M.; Showalter, D.H.; Jacobson, W.C.; Heath, G.E.
Journal of the American Veterinary Medical Association 175(5): 449-452
1979
ISSN/ISBN: 0003-1488 PMID: 500475 Document Number: 144017
Tissue concentrations of sulfadimidine in swine fed the drug at the rate of 500 g/ton of ration (550 g/1 000 kg) for a 30-day period depleted to 0.1 ppm or less within 4 to 10 days after withdrawal of medicated feed. Depletion from the tissues and plasma of treated pigs showed a linear relationship with time when the concentrations were plotted on a semilogarithmic graph. Six untreated pigs that were placed on bedding in pens formerly occupied by the treated group developed tissue residues at or above 0.1 ppm sulfadimidine; the mean plasma concentration of sulfadimidine reached 2.8 ppm by day 15.