In vitro comparative study of the protective effect of different theophyllines on the leucocytes' histamine-release induced by antigen
Biot, N.; Grosclaude, M.; Kofman, J.; Perrin-Fayolle, M.
Le Poumon et le Coeur 36(4): 271-275
1980
ISSN/ISBN: 0032-5821 PMID: 6160569 Document Number: 156882
The protective action of xanthic bases towards histamine-release consecutive to the antigen-antibody reaction was studied. The technique used was that described by Lichtenstein and Osler: isolation of leukocytes, measurement of histamine liberated in the presence of antigen, same measurement done in the presence of antigen and theophylline. The antigens used were: house dust, Dermatophagoides pteronyssimus (DP), Graminaceae pollens. The tested theophyllines were: the theophylline base, aminophylline, bamifylline, diprophylline, thio theo and piperazine acefilinate. All the substances studied reduced histamine-release but according to a variable frequency and intensity: the thio theo, the diprophylline and the piperazine acefyllinate gave the best results especially when the antigen was dust or DP. This study enables the confirmation of the inhibiting action of theophyllines on histamine-release induced by antigen, but complementary studies on a larger number of cases seem necessary to determine precisely the most efficient derivatives.