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Effect of prostaglandins on the activity of the isolated rat heart with normal arterial pressure and spontaneous hypertension

Markov, K.M.; Smirnov, I.E.; Mentts, P.R.

Kardiologiia 20(7): 88-92

1980

ISSN/ISBN: 0022-9040
PMID: 7401444
Document Number: 156317
The article discusses the results of experimental study of the effect of prostaglandins E2, A2, and F2 alpha on coronary blood flow and contractility of an isolated and perfused after Langendorff heart of rats with normal arterial pressure. A substantial reduction of the synthesis of prostacycline and prostaglandin-like compounds in the heart of rats with spontaneous hypertension was found. Marked changes were revealed in the cardiac effects of arachidonic and linoleic acids and changes in the reactivity of the heart of rats with spontaneous hypertension to the injection of isoprenaline, oxyfedrine and verapamil. The role of changes in prostaglandin production in the pathogenesis of myocardial insufficiency in arterial hypertension is discussed.

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