The effect of prostaglandins E1 and F2a on intraocular and arterial pressure
Khurana, I.; Singh, P.I.; Maini, B.K.; Khurana, A.K.
Indian Journal of Ophthalmology 34(1): 53-56
1986
ISSN/ISBN: 0301-4738 PMID: 3481771 Document Number: 282342
The effect of intravenous infusion of prostaglandin E1 (PGE1) and of postaglandin F2a (PFG2a) was studied in rabbits. The IOP showed a rise both with PGE1 and PGF2a: however, the effect produced was significantly greater with PGF2a. The increase in IOP was dose dependent. The threshold dose required to produce an effect was 0.2 .mu.g. Thereafter, there was a linear relationship between the dose administered and increase in IOP up to a dose of 5 .mu.g: with higher dosage the increase in IOP was less marked. Both PGE1 and PGF2a lowered systolic as well as diastolic blood pressure. Fall in blood pressure was related to the dose administred. The blood pressure lowering effect of PGE1 was significantly greater than that of PGF2a.