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Experimental obstructive hydronephrosis in newborn rats. I. Surgical technique and long-term morphologic effects

Josephson, S.; Robertson, B.; Claesson, G.; Wikstad, I.

Investigative Urology 17(6): 478-483

1980

ISSN/ISBN: 0021-0005
PMID: 7372435
Document Number: 155205
Partial obstruction of 1 ureter was created in newborn rats and its effects were studied in the adult rat. The obstructed renal pelvis was enlarged 10 times. The parenchymal weight of this kidney was reduced by 8%, primarily because of destruction of the papilla, and was completely compensated for by hypertrophy of the contralateral kidney. A high correlation was found between true volumes and areas on urography. The turnover time for urine in the hydronephrotic pelvis ranged from 47-473 min. The implications of this measurement for clearance values are discussed.

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