Histophysiologic characteristics of the subcommissural organ during isolated suppression of the functional activity of the zona glomerulosa of the adrenal gland
Gul'iants, E.S.; Siziakina, L.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 90(9): 370-372
1980
ISSN/ISBN: 0365-9615 PMID: 6775711 Document Number: 155204
The effect of prolonged administration of heparin on the histophysiological characteristics of the subcomissural organ (SCO) of the brain and adrenal glomerular zone (AGZ) was studied in 30 male rats. It was established that heparin inhibits the functional activity of AGZ adrenocorticocytes. This is associated with the lowered content of 3-beta-ol-steroid dehydrogenase, RNA, total protein, and a decrease in the zone width (by 50%). Ependimocytes of brain SCO show an abruptly reduced activity of glutamate dehydrogenase, NAD-dependent alpha-glycerophosphate dehydrogenase, lactate dehydrogenase acid phosphatase, which is evidence of their secretory function inhibition. The changes indicate the presence of the functional relationship between the ependimocytes of brain SCO and AGZ adrenocorticocytes as well as to the participation of brain SCO in AGZ function control.