Peripheral nerve allografts. I. Distinctive histological features of nerve degeneration and immunological rejection
Comtet, J.J.; Revillard, J.P.
Transplantation 28(2): 103-106
1979
ISSN/ISBN: 0041-1337 PMID: 483357 Document Number: 153703
Sequential sections were prepared from isografted or allografted sciatic nerves in adult female DBA/2 mice and were compared with Wallerian degeneration in the same inbred strain. Transverse sections were studied by qualitative and quantitative histology. Rejection was manifest by important mononuclear cell infiltration, including large pyroninophilic cells, around the grafted nerve, followed by irregular infiltrate appearance around neovessels within the nerve. Endoneural nuclei number increased less rapidly in allografts than in isografts up to day 15 and diminished thereafter, in association with possible neural vascularization reduction.