Selective inhibition of ribosomal RNA synthesis by rifampicin in E. coli cells
Kliachko, E.V.; Shakulov, R.S.
Biokhimiia 44(8): 1521-1523
1979
ISSN/ISBN: 0320-9725 PMID: 387099 Document Number: 153704
Under partial inhibition of total RNA synthesis by rifampicin the formation of beta- and beta'-subunits of RNA polymerase is stimulated and the rRNA synthesis is selectively repressed. The differential rate of synthesis of the beta- and beta'-subunits increases from 1,15% up to 2,88% in the presence of 30 micrograms rifampicin per ml. Simultaneously the differential rate of rRNA synthesis decreases from 41% down to 10%. The degree of inhibition of rRNA synthesis by rifampicin depends on the cell growth rate.