Changes in serum levels of antibiotics in experimental CCL4 poisoning. I. Gentamycin
Uomo, G.; Roperto, F.; Andini, A.; Capasso, D.; Esposito, S.; Galloro, P.; Guarino, G.; Niola, O.; Ricci, E.
Bollettino della Societa Italiana di Biologia Sperimentale 55(20): 2118-2123
1979
ISSN/ISBN: 0037-8771 PMID: 548043 Document Number: 152641
The AA. studied gentamycin serum levels (1mg/Kg b.w.) in rats. The 50% of the animals studied where treated with CCl4 (1 ml/Kg b;w.) 24h previously, the remaining 50% recieved a placebo. The maximum serum levels where similar in both groups; but the antibiotic was removed more slowly (120-240min) in the groups which recieved CCl4. The slower rimotion rate causes more serious histological changes in the kidney.