The effect of domperidone on pyloric activity in dog and in man
Platteborse, R.; Hermans, C.; Loots, W.; Van Loon, J.; Van Gorp, A.; Smet, F.; Jageneau, A.
Postgraduate Medical Journal 55(Suppl 1): 15-18
1979
ISSN/ISBN: 0032-5473 PMID: 471857 Document Number: 152550
In a study in dogs using ultrasonic transducers to measure degree of pyloric dilatation, it was found that i.v. domperidone (0.35 and 0.7 mg/kg) significantly increased the diameter of the pyloric lumen without affecting the frequency of pyloric relaxations. A subsequent study involving 59 patients referred for upper digestive tract endoscopy, confirmed this increase in diameter of the pylorus which indicates a potential use of domperidone (either i.v. or oral) in the treatment of some forms of dyspepsia characterized by delayed gastric emptying.