Clinical trial on the effect of domperidone on non-ulcer dyspepsia
Sarin, S.K.; Sharma, P.; Chawla, Y.K.; Gopinath, P.; Nundy, S.
Indian Journal of Medical Research 83: 623-628
1986
ISSN/ISBN: 0019-5340 PMID: 3530997 Document Number: 273471
The effect of a two week course of domperidone, a peripheral dopamine antagonist, was evaluated in 44 patients with non-ulcer dyspepsia in a randomised double-blind crossover clinical trial. Compared with placebo, domperidone in a dose of 10 mg tds resulted in significant (p < 0.01) symptomatic improvement in 84 per cent of the patients, with regard to belching, postprandial fullness, abdominal distension and heartburn. Domperidone also led to a significant shortening of gastric emptying time by 28 per cent (p < 0.01). It had no effect on histamine or pentagastrin stimulated acid secretion and it was free of side effects. Domperidone thus deserves a wider application in patients with non-ulcer dyspepsia.