Prevention of stress-induced and hypoxic heart lesions by means of an antioxidant ionol
Meerson, F.Z.; Kagan, V.E.; Golubeva, L.Iu.; Ugolev, A.A.; Shimkovich, M.V.
Kardiologiia 19(8): 108-111
1979
ISSN/ISBN: 0022-9040 PMID: 573812 Document Number: 151213
It was shown in experiments on male Wistar rats that activation of peroxidized oxidation of myocardial lipids and accumulation of hydroperoxides in the myocardium comprise the decisive link of the pathogenic chain of stress and hypoxic damages to the heart. Injection of a potent non-toxic antioxidant into the animals before exposure to the stress or hypoxia blocks the activation of peroxidized oxidation and prevents disorder of the contractile function and damage to the heart muscle appraised according to the elimination of enzymes from the myocardial cells.