Top Abstract Purchase Related
Home
>
Node
>
Subnode

Elimination of disorders of electric stability of the heart during post-infarct cardiosclerosis using adaptation to short-term stress and the antioxidant ionol

Meerson, F.Z.; Belkina, L.M.; Diusenov, S.S.

Biulleten' Eksperimental'noi Biologii i Meditsiny 102(11): 536-539

1986

ISSN/ISBN: 0365-9615
PMID: 3779073
Document Number: 285683
The experiments were carried out on male Wistar rats (300-400 g) subject to open chest surgery under nembutal anesthesia. One group of rats with postinfarction cardiosclerosis (PC) was exposed to short-term immobilization stress for 15 days one month after the occlusion of the descending branch of the left coronary artery. The other group of rats with PC was administered synthetic antioxidant ionol (BHT) (60 mg/kg, per os) 3 days prior to the experiments. The electrical stability of the heart was evaluated by assessing ventricular fibrillation threshold (VFT) determined by stimulation of the right ventricular apex by single premature impulses (10 ms) and by measuring the amount of ectopic beats developing during 30-sec stimulation of the right vagus (2 mA, 20 Hz). VFT in rats with PC was significantly lower, as compared to sham-operated rats (2.9 +/- 0.2 and 6.4 +/- 0.2 mA, respectively), with pronounced extrasystoles appearing during vagal bradycardia. In stress-adapted animals with PC VFT returned to the level of sham-operated rats and the amount of premature beats decreased 3-4-fold, as compared to unadapted rats with PC. Ionol (BHT) was shown to have the same effect.

Document emailed within 1 workday
Secure & encrypted payments

Meerson, F.Z.; Kagan, V.E.; Golubeva, L.Iu.; Ugolev, A.A.; Shimkovich, M.V. 1979: Prevention of stress-induced and hypoxic heart lesions by means of an antioxidant ionol Kardiologiia 19(8): 108-111
Meerson, F.Z.; Malyshev, V.V.; Petrova, V.A.; Lifan't'ev, V.I. 1982: Use of the antioxidant ionol to prevent activation of the pituitary-adrenal system and heart damage during stress Kardiologiia 22(9): 85-89
Meerson, F.Z.; Katkova, L.S.; Malyshev, V.V. 1985: Comparative evaluation of the effect of preliminary adaptation of the body to moderate physical loading and brief stress exposures on heart contractile function disorders in long-term stress Kardiologiia 25(2): 74-77
Semchuk, N.M.; Vasylyk, Y.V.; Lushchak, O.V.; Lushchak, V.I. 2012: Effect of short-term salt stress on oxidative stress markers and antioxidant enzymes activity in tocopherol-deficient Arabidopsis thaliana plants Ukrains'kyi Biokhimichnyi Zhurnal 84(4): 41-48
Meerson, F.Z.; Miniaĭlenko, T.D.; Pozharov, V.P. 1993: Development of super-resistance to hypoxic hypoxia during adaptation to short-term stress Biulleten' Eksperimental'noi Biologii i Meditsiny 115(2): 132-135
Shkliar, A.S. 1980: Effect of the antioxidant, ionol, on blood coagulation in ischemic heart disease Vrachebnoe Delo 9: 52-54
Sopić, M.; Bogavac-Stanojević, N.; Baralić, I.; Kotur-Stevuljević, J.; Đorđević, B.; Stefanović, A.; Jelić-Ivanović, Z. 2014: Effects of short- and long-term physical activity on DNA stability and oxidative stress status in young soccer players Journal of Sports Medicine and Physical Fitness 54(3): 354-361
Meerson, F.Z.; Nurmukhambetov, A.N.; Dzhanbaeva, G.E.; Gutkin, D.V. 1987: Free-radical lipid oxidation and DNA synthesis in the heart in adriablastin-induced cardiomyopathy and the action of the antioxidant ionol Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 4: 66-68
Belkina, L.M.; Vovk, V.I.; Meerson, F.Z. 1992: Effects of synthetic antioxidant ionol on bioelectric activity of cardiomyocytes and arrhythmia in global ischemia and reperfusion of the isolated rat heart Biulleten' Eksperimental'noi Biologii i Meditsiny 113(4): 367-370
Gorizontova, M.P.; Chernukh, A.M. 1976: Microcirculatory and vascular permeability disorders during short-term immobilization stress Biulleten' Eksperimental'noi Biologii i Meditsiny 81(6): 645-647
Rezin, V.A. 1989: Correction of disorders of the system of blood aggregation regulation by ionol in the post-resuscitation period Biulleten' Eksperimental'noi Biologii i Meditsiny 108(11): 540-542
Mikhalev, V.V. 1971: Blood coagulation and the physico-chemical properties of the fibrin-thrombocytic structure of the clot in patients with post-infarct cardiosclerosis Terapevticheskii Arkhiv 43(8): 99-102
Solenkova, N.V.; Maslov, L.N.; Lishmanov, I.B.; Serebrov, V.I.; Bogomaz, S.A.; Gross, G.G.; Stefano, J.B.; Tam, S.V. 2002: Stimulation of delta1-opioid receptors increases the ventricular fibrillation threshold in post-infarct cardiosclerosis: the role of K(ATP)-channels Eksperimental'naia i Klinicheskaia Farmakologiia 65(1): 30-33
Kettner, W.; Banditt, P.; Walther, H. 1984: Lidocaine elimination and dose adjustment in acute heart infarct and heart insufficiency Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 39(14): 335-342
Golubeva, L.I.; Dvoriantsev, S.N.; Khatkevich, A.N.; Malyshev, I.I.; Meerson, F.Z. 1995: Adaptation to hypoxia, as opposed to adaptation to stress, does not protect the isolated heart from reperfusion after total ischemia. a nuclear magnetic resonance study Biulleten' Eksperimental'noi Biologii i Meditsiny 120(11): 481-484
Kizichenko, N.V.; Arkhipenko, I.V. 1998: Protective effect of stress adaptation to damages caused hemorrhagic shock: the role of the antioxidant system Biulleten' Eksperimental'noi Biologii i Meditsiny 126(9): 270-273
Actis-Dato, A.; Panero, G.B.; De Giorgi, E.; Baldrighi, G.; Forzani, T. 1972: Elimination of akinetic ventricular zones in chronic post-infarct decompensation (report on 18 personal cases) Bollettino Della Societa Italiana di Cardiologia 17(10): 848-850
Chvyrev, V.G.; Novozhilov, G.N.; Merkushev, I.A. 1990: Energy metabolism during short-term thermal adaptation Gigiena Truda i Professional'nye Zabolevaniya (2): 35-38
Kalytka, V.V.; Savrans'ka, O.V.; Kaluhina, I.P. 1994: Effect of ionol and dimethylsulfoxide on activity of enzymes of the antioxidant system in chickens Ukrainskii Biokhimicheskii Zhurnal 66(5): 27-31
Kuz'menko, I.V.; Kunitsa, N.I.; Donchenko, G.V. 1993: Effect of tocopherol, its analogs and the antioxidant ionol on lipid peroxidation in vitro Ukrainskii Biokhimicheskii Zhurnal 65(3): 94-99