The influence of 2-acetylaminofluorene on the dietary induction of pentose phosphate pathway enzymes
Fischer, W.; Grund, E.
Archiv für Geschwulstforschung 49(5): 381-385
1979
ISSN/ISBN: 0003-911X PMID: 518247 Document Number: 150802
The influence of feeding 2-acetylaminofluorene on the dietary induction of the enzymes glucose-6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase by a fasting-refeeding regime was investigated in the liver of hooded rats. After feeding a diet containing 0,03% acetylaminofluorene for two weeks, the induced activity of glucose-6-phosphate dehydrogenase was diminished significantly; after feeding this carcinogen either for 4 weeks or for 4 weeks followed by feeding carcinogen-free diet for 2 weeks, the diminution of the induction was hardly perceptible. In case of 6-phosphogluconate dehydrogenase the diminution of the induction was only slightly expressed, without statistical significance.