Tissue-specific features of the pentose phosphate pathway in rats under acute alcoholic intoxication conditions
Lelevich, S.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 71(2): 53-55
2008
ISSN/ISBN: 0869-2092 PMID: 18488910 Document Number: 616602
The activity of pentose phosphate pathway (PPP) in the liver and skeletal muscles of rats has been studied after acute alcohol administration in a dose of 1, 2.5, and 5 g/kg body weight. Inhibition of the activity of the main PPP enzymes as well as a decrease in the liver pentose level in rats as a result of alcohol intoxication have been observed. In muscle tissues, alcohol leads to the activation of glucose-6-phosphate-dehydrogenase and the inhibition of the transketolase activity.