Anthelminthic activity of oxfendazole in gastrointestinal parasitism in sheep
González, H.; Plaza, J.; Aguirre, F.
Boletin Chileno de Parasitologia 34(3-4): 72-75
1979
ISSN/ISBN: 0365-9402 PMID: 549575 Document Number: 146327
A comparative study of the antihelminthic activity of different doses of oxfendazole in sheep was carried out. Forty-three 8 mo. old sheep, with natural gastrointestinal infections by Strongyloides, were distributed into 4 groups and treated with a single dose of 1 of the drugs as follows: 10 untreated (control group), 11 treated with oxfendazole 2.5 mg/kg, 11 treated with oxfendazole 5.0 mg/kg and 11 treated with fenbendazole 5.0 mg/kg. The different groups of animals were maintained indoors and periodical fecal examinations were done 12 days before and 35 days after treatment using a modified McMaster method for each animal. Weight controls were done 3 times during the experiment. At the termination of the experiment, all animals were slaughtered to count the adult parasites. A 100% effectivity in the Strongyloides egg reduction, was observed 35 days after treatment in groups receiving oxfendazole (2.5 and 5.0 mg/kg). The average results from necropsies were: 100% cure in infections concerning the abomasum in all treated groups, 99.4% cure with oxfendazole, 100% cure with fenbendazole concerning small intestinal infections and 100% cure for both drugs concerning large intestinal infections. The exception was Trichuris ovis, in which there was only a 29.2% success.