Potentiation of anticancer effect of carboquone in vivo by glucose pretreatment
Baba, T.; Aoki, K.; Kimura, N.T.; Kamura, T.; Nishikawa, K.; Taniguchi, S.
Gan 70(2): 255-258
1979
ISSN/ISBN: 0016-450X PMID: 467889 Document Number: 144378
Anticancer effect of carboquone was notably potentiated in tumor-bearing mice when they were pretreated with 5% glucose solution in the system of blood flow-interrupting hyperthermic chemotherapy. It was further found by quantitative analysis that the potentiation was much greater than increase in the general toxicity of the drug by administration of glucose. Mitomycin-C, on the other hand, revealed no such marked effect though it is considerably similar to carboquone in chemical structure.