Recovery of MAO-B enzyme activity after (-) deprenyl (selegiline) pretreatment, measured in vivo
Timár, J.
Acta Physiologica Hungarica 74(3-4): 259-266
1989
ISSN/ISBN: 0231-424X PMID: 2517980 Document Number: 340939
The recovery of MAO-B activity after a single dose of 0.25 mg/kg s.c. (-)deprenyl was measured in rat, by following the time course of the changes in the PEA (phenyl-ethylamine)-induced hyperactivity. One hour after its administration (-)deprenyl enhanced both the PEA-induced locomotion and stereotypy, however, its effect on the latter was more marked. At 24 h and at later time-points only stereotype was enhanced. The results show that a single small dose of (-)deprenyl which selectively blocks MAO-B, causes a long-lasting inhibition of PEA metabolism, and the enzyme activity needs more than one week to restore completely.