Valyl-proline as an index of elastin biosynthesis
Hauschka, P.V.; Gallop, P.M.
Analytical Biochemistry 92(1): 61-66
1979
ISSN/ISBN: 0003-2697 PMID: 426288 Document Number: 143548
A new approach to evaluate elastin biosynthesis in minced mouse lung tissue is introduced using ion exchange chromatography. Synthesis of proelastin, proteolysis and posttranslational enzyme modification of elastin biosynthetic precursors are described. This method is suggested to estimate the degree of lung collagen development in animals.
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