Functional activity of T and B lymphocytes of mice undergoing spontaneous loss of tolerance
Kondrat'eva, I.A.; Novikova, T.K.; Fontalin, L.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 88(9): 314-317
1979
ISSN/ISBN: 0365-9615 PMID: 316340 Document Number: 143415
The functional activity of splenocytes and thymocytes of mice tolerant to sheep red blood cells was investigated one and four weeks after tolerance induction. The tolerance was achieved by cyclophosphamide. The immunocompetence of thymocytes was fully reversed in lfour week time. The functional activity of T and B lymphocytes of the spleen was also partially recovered four weeks after tolerance induction. Preliminary thymectomy weakened but did not prevent completely the immunocompetence of T cells of the spleen from being recovered. No Tsuppressants were found in the thymus or spleen of the tolerant animals.